Depurination is aspontaneous chemical processes that is known to cause the most severe DNA damage in cells. DNA can be depurinated to liberate guanine and adenine.
The DNA molecule either has the typical sequence or lacks one nucleotide pair.
A daughter DNA molecule can be produced during the replication of a double-stranded DNA molecule that has experienced depurination on an A or G nucleotide on one of the strands, depending on whether the sequence is normal or not.
The replication machinery can simply skip over the depurinated base and go to the following nucleotide on the strand that contains the damaged nucleotide, generating a daughter DNA molecule that is missing that entire nucleotide pair.
Since the sequence is unaltered on the other DNA strand, a normal, complementary daughter strand is created during replication, resulting in a double-stranded DNA with all of its typical properties. It's crucial to keep in mind that a cell's regular DNA machinery.
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