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bobeld
The smallest (whole number ) 6 digit number is 1,000,000
The greatest (whole number 4 digit number is 9,999
The difference between them means to subtract the four digit number from the 6 digit number.
The difference is 990,001

I would not consider 000001 to be a 6 digit number (in case this is supposed to be a trick question.)
AL2006
Working with whole numbers only ... the smallest 6-digit number is 100,000, the greatest 4-digit one is 9,999, and their difference is 90,001 .